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Article

The prevalence and antifolate drug resistance profiles of Plasmodium falciparum in study participants randomized to discontinue or continue cotrimoxazole prophylaxis.

PLoS neglected tropical diseases - 1 Mar 2019

Juma Dennis W, Muiruri Peninah, Yuhas Krista, John-Stewart Grace, Ottichilo Ronald, Waitumbi John, Singa Benson, Polyak Christina, Kamau Edwin

Abstract excerpt

OBJECTIVE: Cotrimoxazole prevents opportunistic infections including falciparum malaria in HIV-infected individuals but there are concerns of cross-resistance to other antifolate drugs such as sulphadoxine-pyrimethamine (SP). In this study, we investigated the prevalence of antifolate-resistance mutations in Plasmodium falciparum that are associated with SP resistance in HIV-infected individuals on antiretroviral...

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Identifiers

PMID: 30897090
DOI: 10.1371/journal.pntd.0007223
PMCID: PMC6445470

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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