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Increased methylation upstream of the MEG3 promotor is observed in acute myeloid leukemia patients with better overall survival

15 Mar 2019

Abstract excerpt

BACKGROUND: The delta-like non-canonical Notch ligand 1 (DLK1)-maternally expressed 3(MEG3) locus (DLK1-MEG3 locus) plays a critical role in the maintenance and differentiation of hematopoietic stem cells. Accumulating evidence implicates the imprinted genes from this locus, DLK1 and MEG3, in the development and progression of acute myeloid leukemia (AML). However, the contribution of this locus to the treatment...

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PMID: 30876483
DOI: 10.1186/s13148-019-0643-z

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