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Article

STAT5 drives abnormal proliferation in autosomal dominant polycystic kidney disease.

Kidney international - 1 Mar 2017

Fragiadaki Maria, Lannoy Morgane, Themanns Madeleine, Maurer Barbara, Leonhard Wouter N, Peters Dorien J M, Moriggl Richard, Ong Albert C M

Abstract excerpt

Autosomal dominant polycystic kidney disease (ADPKD) leads to renal failure. The hallmark of ADPKD is increased epithelial proliferation, which has been proposed to be due to atypical signaling including abnormal JAK-STAT activity. However, the relative contribution of JAK-STAT family members in promoting proliferation in ADPKD is unknown. Here, we present siRNA JAK-STAT-focused screens discovering a previously...

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Source

Identifiers

PMID: 28104302
DOI: 10.1016/j.kint.2016.10.039

Genes

STAT1
STAT2
STAT4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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