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Article

Autoimmune genetic risk variants as germline biomarkers of response to melanoma immune-checkpoint inhibition.

Cancer immunology, immunotherapy : CII - 1 Jun 2019

Chat Vylyny, Ferguson Robert, Simpson Danny, Kazlow Esther, Lax Rebecca, Moran Una, Pavlick Anna, Frederick Dennie, Boland Genevieve, Sullivan Ryan, Ribas Antoni, Flaherty Keith, Osman Iman, Weber Jeffrey, Kirchhoff Tomas

Abstract excerpt

Immune-checkpoint inhibition (ICI) treatments improve outcomes for metastatic melanoma; however, > 60% of treated patients do not respond to ICI. Current biomarkers do not reliably explain ICI resistance. Given the link between ICI and autoimmunity, we investigated if genetic susceptibility to autoimmunity modulates ICI efficacy. In 436 patients with metastatic melanoma receiving single line ICI or combination...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 30863922
DOI: 10.1007/s00262-019-02318-8
PMCID: PMC6531317

Genes

IL2
IL21

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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