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Characterization of a novel murine Sost ERT2 Cre model targeting osteocytes

21 Feb 2019

Abstract excerpt

Abstract Transgenic mice are widely used to delete or overexpress genes in a cell specific manner to advance knowledge of bone biology, function and disease. While numerous Cre models exist to target gene recombination in osteoblasts and osteoclasts, few target osteocytes specifically, particularly mature osteocytes. Our goal was to create a spatial and temporal conditional Cre model using tamoxifen to induce Cre...

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PMID: 30820362
DOI: 10.1038/s41413-018-0037-4

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