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Article

The long-term prognostic and predictive capacity of cyclin D1 gene amplification in 2305 breast tumours

28 Feb 2019

Abstract excerpt

BACKGROUND: Use of cyclin D1 (CCND1) gene amplification as a breast cancer biomarker has been hampered by conflicting assessments of the relationship between cyclin D1 protein levels and patient survival. Here, we aimed to clarify its prognostic and treatment predictive potential through comprehensive long-term survival analyses. METHODS: CCND1 amplification was assessed using SNP arrays from two cohorts of 1965...

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PMID: 30819233
DOI: 10.1186/s13058-019-1121-4

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