Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

MUC16 impacts tumor proliferation and migration through cytoplasmic translocation of P120-catenin in epithelial ovarian cancer cells: an original research

22 Feb 2019

Abstract excerpt

BACKGROUND: Epithelial ovarian cancer (EOC) remains one of the most lethal gynecologic cancers, and its pathogenetic mechanism remains unclear. Here we show that MUC16 promotes the translocation of p120-catenin (p120ctn) to the cytoplasm and consequently activates ras homolog (Rho) GTPases RhoA/Cdc42 activation to modulate the proliferation and migration abilities of EOC cells. METHODS: We collect 94 ovarian...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to 14-3-3 protein interactions
Share to Microtubule and mitosis dynamics
Share to Ovarian cancer diagnosis and treatment

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 30795761
DOI: 10.1186/s12885-019-5371-4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

MUC16 impacts tumor proliferation and migration through cytoplasmic translocation of P120-catenin in epithelial ovarian cancer cells: an original researchPMID 30795761Read ↗

MUC16 mutations improve patients’ prognosis by enhancing the infiltration and antitumor immunity of cytotoxic T lymphocytes in the endometrial cancer microenvironmentSemantic proximity Read ↗

Long non-coding RNA ASB16-AS1 enhances cell proliferation, migration and invasion via functioning as a ceRNA through miR-1305/Wnt/β-catenin axis in cervical cancerSemantic proximity Read ↗

The evolving role of MUC16 (CA125) in the transformation of ovarian cells and the progression of neoplasiaSemantic proximity Read ↗

Introducing the MUC16 gene: implications for prevention and early detection in epithelial ovarian cancer.Semantic proximity Read ↗

MUC16: molecular analysis and its functional implications in benign and malignant conditionsSemantic proximity Read ↗

HPV16 E6 oncoprotein‐induced upregulation of lncRNA GABPB1‐AS1 facilitates cervical cancer progression by regulating miR‐519e‐5p/Notch2 axisSemantic proximity Read ↗

TMEM176B inhibits ovarian cancer progression by regulating EMT via the Wnt/β-catenin signaling pathwaySemantic proximity Read ↗

Calcium Binding Protein S100A16 Expedites Proliferation, Invasion and EMT Process in Gastric CancerSemantic proximity Read ↗

Integrative analysis of the cancer genome atlas and cancer cell lines encyclopedia large-scale genomic databases: MUC4/MUC16/MUC20 signature is associated with poor survival in human carcinomasSemantic proximity Read ↗

Truncated O-Glycan-Bearing MUC16 Enhances Pancreatic Cancer Cells Aggressiveness via α4β1 Integrin Complexes and FAK SignalingSemantic proximity Read ↗

Association of MUC16 Mutation With Tumor Mutation Load and Outcomes in Patients With Gastric Cancer.Semantic proximity Read ↗

CircMUC16 promotes autophagy of epithelial ovarian cancer via interaction with ATG13 and miR-199aSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.