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Integrator is a key component of human telomerase RNA biogenesis

8 Feb 2019

Abstract excerpt

Telomeres are special DNA-protein structures that are located at the ends of linear eukaryotic chromosomes. The telomere length determines the proliferation potential of cells. Telomerase is a key component of the telomere length maintenance system. While telomerase is inactive in the majority of somatic cells, its activity determines the clonogenic potential of stem cells as a resource for tissue and organism...

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PMID: 30737432
DOI: 10.1038/s41598-018-38297-6

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