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Article

Human megakaryocytes possess intrinsic antiviral immunity through regulated induction of IFITM3

5 Feb 2019

Abstract excerpt

Evolving evidence indicates that platelets and megakaryocytes (MKs) have unexpected activities in inflammation and infection; whether viral infections upregulate biologically active, antiviral immune genes in platelets and MKs is unknown, however. We examined antiviral immune genes in these cells in dengue and influenza infections, viruses that are global public health threats. Using complementary biochemical,...

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Identifiers

PMID: 30723081
DOI: 10.1182/blood-2018-09-873984

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