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Article

miR-132-3p is a positive regulator of alpha-cell mass and is downregulated in obese hyperglycemic mice

18 Jan 2019

Abstract excerpt

OBJECTIVE: Diabetes is a complex disease implicating several organs and cell types. Within the islets, dysregulation occurs in both alpha- and beta-cells, leading to defects of insulin secretion and increased glucagon secretion. Dysregulation of alpha-cells is associated with transcriptome changes. We hypothesized that microRNAs (miRNAs) which are negative regulators of mRNA stability and translation could be...

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PMID: 30711402
DOI: 10.1016/j.molmet.2019.01.004

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