Article
The Landscape of microRNAs in βCell: Between Phenotype Maintenance and Protection.
International journal of molecular sciences - 14 Jan 2021
Grieco Giuseppina Emanuela, Brusco Noemi, Licata Giada, Fignani Daniela, Formichi Caterina, Nigi Laura, Sebastiani Guido, Dotta Francesco
Abstract excerpt
Diabetes mellitus is a group of heterogeneous metabolic disorders characterized by chronic hyperglycaemia mainly due to pancreatic β cell death and/or dysfunction, caused by several types of stress such as glucotoxicity, lipotoxicity and inflammation. Different patho-physiological mechanisms driving β cell response to these stresses are tightly regulated by microRNAs (miRNAs), a class of negative regulators of...
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