Article
Role of MicroRNAs in Islet Beta-Cell Compensation and Failure during Diabetes
1 Jan 2014
Abstract excerpt
Pancreatic beta-cell function and mass are markedly adaptive to compensate for the changes in insulin requirement observed during several situations such as pregnancy, obesity, glucocorticoids excess, or administration. This requires a beta-cell compensation which is achieved through a gain of beta-cell mass and function. Elucidating the physiological mechanisms that promote functional beta-cell mass expansion...
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