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Differentially Expressed MicroRNA-483 Confers Distinct Functions in Pancreatic β- and α-Cells

25 Jun 2015

Abstract excerpt

Insulin secreted from pancreatic β-cells and glucagon secreted from pancreatic α-cells are the two major hormones working in the pancreas in an opposing manner to regulate and maintain a normal glucose homeostasis. How microRNAs (miRNAs), a population of non-coding RNAs so far demonstrated to be differentially expressed in various types of cells, regulate gene expression in pancreatic β-cells and its closely...

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PMID: 26109062
DOI: 10.1074/jbc.m115.650705

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