Article
Therapeutic Inhibition of miR-33 Promotes Fatty Acid Oxidation but Does Not Ameliorate Metabolic Dysfunction in Diet-Induced Obesity.
Arteriosclerosis, thrombosis, and vascular biology - 1 Dec 2015
Karunakaran Denuja, Richards Laura, Geoffrion Michele, Barrette Danyk, Gotfrit Ryan J, Harper Mary-Ellen, Rayner Katey J
Abstract excerpt
OBJECTIVE: miR-33 has emerged as an important regulator of lipid homeostasis. Inhibition of miR-33 has been demonstrated as protective against atherosclerosis; however, recent studies in mice suggest that miR-33 inhibition may have adverse effects on lipid and insulin metabolism. Given the therapeutic interest in miR-33 inhibitors for treating atherosclerosis, we sought to test whether pharmacologically...
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