Can Mendelian Randomization Shift into Reverse Gear?

Abstract excerpt

Mendelian randomization (MR),7 a genetic epidemiological approach, has made substantial inroads into our understanding of the causes, and consequences, of disease (1, 2). Conventionally, MR takes genetic variants associated with an exposure to estimate the causal effect on risk of disease. Availability of large-scale data and hypothesis-free genome-wide analyses has led to discovery of trait-associated genetic...

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