Why clinicians should know about Mendelian randomization

Abstract excerpt

Randomized controlled trials (RCTs) sit at the pinnacle of the hierarchy of evidence, but conducting an RCT is not always practical or ethical. We must be cautious about using observational studies as a basis for action, since the complex network of causes in the real world means that it is impossible to entirely eliminate confounding factors. Correlation, as they say, is not causation. But what if there were a...

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