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Mutational Patterns in Metastatic Cutaneous Squamous Cell Carcinoma

24 Jan 2019

Abstract excerpt

Cutaneous squamous cell carcinoma from the head and neck typically metastasize to the lymph nodes of the neck and parotid glands. When a primary is not identified, they are difficult to distinguish from metastases of mucosal origin and primary salivary gland squamous cell carcinoma. UV radiation causes a mutation pattern that predominantly features cytosine to thymine transitions at dipyrimidine sites and has...

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PMID: 30684551
DOI: 10.1016/j.jid.2019.01.008

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