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Mendelian Randomization Analysis of Hemoglobin A1c as a Risk Factor for Coronary Artery Disease

19 Jan 2019

Abstract excerpt

OBJECTIVE Observational studies show that higher hemoglobin A1c (A1C) predicts coronary artery disease (CAD). It remains unclear whether this association is driven entirely by glycemia. We used Mendelian randomization (MR) to test whether A1C is causally associated with CAD through glycemic and/or nonglycemic factors. RESEARCH DESIGN AND METHODS To examine the association of A1C with CAD, we selected 50...

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PMID: 30659074
DOI: 10.2337/dc18-1712

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