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Article

Endogenous HMGB1 regulates autophagy.

The Journal of cell biology - 6 Sept 2010

Tang Daolin, Kang Rui, Livesey Kristen M, Cheh Chun-Wei, Farkas Adam, Loughran Patricia, Hoppe George, Bianchi Marco E, Tracey Kevin J, Zeh Herbert J, Lotze Michael T

Abstract excerpt

Autophagy clears long-lived proteins and dysfunctional organelles and generates substrates for adenosine triphosphate production during periods of starvation and other types of cellular stress. Here we show that high mobility group box 1 (HMGB1), a chromatin-associated nuclear protein and extracellular damage-associated molecular pattern molecule, is a critical regulator of autophagy. Stimuli that enhance...

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Source

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Identifiers

PMID: 20819940
DOI: 10.1083/jcb.200911078
PMCID: PMC2935581

Genes

HMGB1

Provenance

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