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Article

Discovering putative prion sequences in complete proteomes using probabilistic representations of Q/N-rich domains

10 May 2013

Abstract excerpt

BACKGROUND: Prion proteins conform a special class among amyloids due to their ability to transmit aggregative folds. Prions are known to act as infectious agents in neurodegenerative diseases in animals, or as key elements in transcription and translation processes in yeast. It has been suggested that prions contain specific sequential domains with distinctive amino acid composition and physicochemical...

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PMID: 23663289
DOI: 10.1186/1471-2164-14-316

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