Article
The heat-shock response co-inducer arimoclomol protects against retinal degeneration in rhodopsin retinitis pigmentosa.
Cell death & disease - 22 May 2014
Parfitt D A, Aguila M, McCulley C H, Bevilacqua D, Mendes H F, Athanasiou D, Novoselov S S, Kanuga N, Munro P M, Coffey P J, Kalmar B, Greensmith L, Cheetham M E
Abstract excerpt
Retinitis pigmentosa (RP) is a group of inherited diseases that cause blindness due to the progressive death of rod and cone photoreceptors in the retina. There are currently no effective treatments for RP. Inherited mutations in rhodopsin, the light-sensing protein of rod photoreceptor cells, are the most common cause of autosomal-dominant RP. The majority of mutations in rhodopsin, including the common P23H...
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