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Article

Retinal Organoid Models Show Heterozygous Rhodopsin Mutation Favors Endoplasmic Reticulum Stress-Induced Apoptosis in Rods.

Stem cells and development - 1 Nov 2023

Yang Qiaohui, Li Jialin, Zeng Sicong, Li Zhuo, Liu Xiao, Li Jin, Zhou Wang, Chai Yujiao, Zhou Di

Abstract excerpt

Retinitis pigmentosa (RP) is a prevalent inherited retinal degenerative disease resulting from photoreceptor and pigment epithelial apoptosis. The Rhodopsin (RHO) is the most commonly associated pathogenic gene in RP. However, RHO mutations (c.512C>T P171L) have been infrequently reported, and the RP pathogenesis caused by these mutations remains unclear. The objective of this study was to investigate the impact...

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PMID: 37470211
DOI: 10.1089/scd.2023.0034

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Retinal Organoid Models Show Heterozygous Rhodopsin Mutation Favors Endoplasmic Reticulum Stress-Induced Apoptosis in Rods.PMID 37470211Read ↗

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