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Article

FAK alternative splice mRNA variants expression pattern in colorectal cancer

10 Jan 2019

Abstract excerpt

The Focal adhesion kinase (FAK) is a ubiquitous cytoplasmic tyrosine‐kinase promoting tumor progression and metastasis processes by acting in cancer cells and their tumor microenvironment partners. FAK overexpression in primary colon tumors and their metastasis is associated to poor colorectal cancer (CRC) patients’ outcome. Eight FAK mRNA alternative splice variants have been described and contribute to...

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PMID: 30628725
DOI: 10.1002/ijc.32120

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