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Article

Milk biosynthesis requires the Golgi cation exchanger TMEM165

8 Jan 2019

Abstract excerpt

Milk is a hallmark of mammals that is critical for normal growth and development of offspring. During biosynthesis of lactose in the Golgi complex, H + is produced as a by-product, and there is no known mechanism for maintaining luminal pH within the physiological range. Here, using conditional, tissue-specific knockout mice, immunostaining, and biochemical assays, we test whether the putative H + /Ca 2+ /Mn 2+...

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PMID: 30622138
DOI: 10.1074/jbc.ra118.006270

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