Article
Manganese-induced turnover of TMEM165.
The Biochemical journal - 19 Apr 2017
Potelle Sven, Dulary Eudoxie, Climer Leslie, Duvet Sandrine, Morelle Willy, Vicogne Dorothée, Lebredonchel Elodie, Houdou Marine, Spriet Corentin, Krzewinski-Recchi Marie-Ange, Peanne Romain, Klein André, de Bettignies Geoffroy, Morsomme Pierre, Matthijs Gert, Marquardt Thorsten, Lupashin Vladimir, Foulquier François
Abstract excerpt
TMEM165 deficiencies lead to one of the congenital disorders of glycosylation (CDG), a group of inherited diseases where the glycosylation process is altered. We recently demonstrated that the Golgi glycosylation defect due to TMEM165 deficiency resulted from a Golgi manganese homeostasis defect and that Mn2+ supplementation was sufficient to rescue normal glycosylation. In the present paper, we highlight TMEM165...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.