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Article

The yeast protein Gdt1p transports Mn2+ ions and thereby regulates manganese homeostasis in the Golgi.

The Journal of biological chemistry - 25 May 2018

Thines Louise, Deschamps Antoine, Sengottaiyan Palanivelu, Savel Oksana, Stribny Jiri, Morsomme Pierre

Abstract excerpt

The uncharacterized protein family 0016 (UPF0016) is a family of secondary ion transporters implicated in calcium homeostasis and some diseases. More precisely, genetic variants of the human UPF0016 ortholog transmembrane protein 165 (TMEM165) have been linked to congenital disorders of glycosylation (CDG). The Saccharomyces cerevisiae ortholog Gdt1p has been shown to be involved in calcium homeostasis and...

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Identifiers

PMID: 29632074
DOI: 10.1074/jbc.RA118.002324
PMCID: PMC5971465

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The yeast protein Gdt1p transports Mn2+ ions and thereby regulates manganese homeostasis in the Golgi.PMID 29632074Read ↗

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