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Article

Investigating the functional link between TMEM165 and SPCA1.

The Biochemical journal - 15 Nov 2019

Lebredonchel Elodie, Houdou Marine, Hoffmann Hans-Heinrich, Kondratska Kateryna, Krzewinski Marie-Ange, Vicogne Dorothée, Rice Charles M, Klein André, Foulquier François

Abstract excerpt

TMEM165 was highlighted in 2012 as the first member of the Uncharacterized Protein Family 0016 (UPF0016) related to human glycosylation diseases. Defects in TMEM165 are associated with strong Golgi glycosylation abnormalities. Our previous work has shown that TMEM165 rapidly degrades with supraphysiological manganese supplementation. In this paper, we establish a functional link between TMEM165 and SPCA1, the...

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Identifiers

PMID: 31652305
DOI: 10.1042/BCJ20190488

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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