USP16 regulates castration-resistant prostate cancer cell proliferation by deubiquitinating and stablizing c-Myc

Abstract excerpt

BACKGROUND: c-Myc, a well-established oncogene, plays an important role in the initiation and progression of various cancers, including prostate cancer. However, its mechanism in cancer cell remains largely unknown and whether there exist a deubiquitinase targeting c-Myc also remains elusive. METHODS: Bioinformatic analysis and shRNA screening methods were used to identify potential deubiquitinases that correlate...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Heat shock proteins research
• Share to Prostate Cancer Treatment and Research
• Share to Ubiquitin and proteasome pathways