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Cytogenetic complexity in chronic lymphocytic leukemia: definitions, associations, and clinical impact

2 Jan 2019

Abstract excerpt

Abstract Recent evidence suggests that complex karyotype (CK) defined by the presence of ≥3 chromosomal aberrations (structural and/or numerical) identified by using chromosome-banding analysis (CBA) may be relevant for treatment decision-making in chronic lymphocytic leukemia (CLL). However, many challenges toward the routine clinical application of CBA remain. In a retrospective study of 5290 patients with...

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PMID: 30602617
DOI: 10.1182/blood-2018-09-873083

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