Chromosome banding analysis and genomic microarrays are both useful but not equivalent methods for genomic complexity risk stratification in chronic lymphocytic leukemia patients.

doi:10.3324/haematol.2020.274456

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Chromosome banding analysis and genomic microarrays are both useful but not equivalent methods for genomic complexity risk stratification in chronic lymphocytic leukemia patients.

Haematologica - 1 Mar 2022

Ramos-Campoy Silvia, Puiggros Anna, Beà Sílvia, Bougeon Sandrine, Larráyoz María José, Costa Dolors, Parker Helen, Rigolin Gian Matteo, Ortega Margarita, Blanco María Laura, Collado Rosa, Salgado Rocío, Baumann Tycho, Gimeno Eva, Moreno Carolina, Bosch Francesc, Calvo Xavier, Calasanz María José, Cuneo Antonio, Strefford Jonathan C, Nguyen-Khac Florence, Oscier David, Haferlach Claudia, Schoumans Jacqueline, Espinet Blanca

Abstract excerpt

Genome complexity has been associated with poor outcome in patients with chronic lymphocytic leukemia (CLL). Previous cooperative studies established five abnormalities as the cut-off that best predicts an adverse evolution by chromosome banding analysis (CBA) and genomic microarrays (GM). However, data comparing risk stratification by both methods are scarce. Herein, we assessed a cohort of 340 untreated CLL...

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PMID: 33691382
DOI: 10.3324/haematol.2020.274456
PMCID: PMC8883543

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