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The complex karyotype and chronic lymphocytic leukemia: prognostic value and diagnostic recommendations

10 Aug 2020

Abstract excerpt

Chromosomal abnormalities are frequently observed in patients with chronic lymphocytic leukemia (CLL) and have prognostic value. Deletions of the short arm of chromosome 17 (and/or mutations TP53) predict resistance to chemoimmunotherapy and shorter progression-free survival after targeted therapies. Although the complex karyotype (CK) is strongly predictive of a poor prognosis in hematologic malignancies such...

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PMID: 32777106
DOI: 10.1002/ajh.25956

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