Article
Major prognostic value of complex karyotype in addition to TP53 and IGHV mutational status in first-line chronic lymphocytic leukemia.
Hematological oncology - 1 Dec 2017
Le Bris Yannick, Struski Stéphanie, Guièze Romain, Rouvellat Caroline, Prade Naïs, Troussard Xavier, Tournilhac Olivier, Béné Marie C, Delabesse Eric, Ysebaert Loïc
Abstract excerpt
Chronic lymphocytic leukemia (CLL) is a lymphoproliferative disorder of remarkable heterogeneity as demonstrated by cytogenetics and molecular analyses. Complex karyotype (CK), TP53 deletions and/or mutations (TP53 disruption), IGVH mutational status, and, more recently, recurrent somatic mutations have been identified as prognostic markers in CLL. On a cohort of 110 patients with CLL treated with first-line...
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