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Article

miR-449a targets HDAC-1 and induces growth arrest in prostate cancer.

Oncogene - 9 Apr 2009

Noonan E J, Place R F, Pookot D, Basak S, Whitson J M, Hirata H, Giardina C, Dahiya R

Abstract excerpt

Histone deacetylases (HDACs) are frequently overexpressed in broad range of cancer types, where they alter cellular epigenetic programming to promote cell proliferation and survival. However, the mechanism by which HDACs become overexpressed in human cancers remains somewhat of a mystery. In this study, we investigated the expression and functional significance of miR-449a in prostate cancer cells. Using...

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Share to Cyclin-Dependent Kinase Inhibitor p27
Share to Gene Expression Regulation, Enzymologic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Intracellular Signaling Peptides and Proteins

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Identifiers

PMID: 19252524
DOI: 10.1038/onc.2009.19

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