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Pharmacogenomics Biomarker Discovery and Validation for Translation in Clinical Practice

22 Oct 2020

Abstract excerpt

Interindividual variability in drug efficacy and toxicity is a major challenge in clinical practice. Variations in drug pharmacokinetics (PKs) and pharmacodynamics (PDs) can be, in part, explained by polymorphic variants in genes encoding drug metabolizing enzymes and transporters (absorption, distribution, metabolism, and excretion) or in genes encoding drug receptors. Pharmacogenomics (PGx) has allowed the...

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PMID: 33089968
DOI: 10.1111/cts.12869

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