Evaluating the role of the FUS/TLS-related gene EWSR1 in amyotrophic lateral sclerosis.

doi:10.1093/hmg/dds116

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Article

Evaluating the role of the FUS/TLS-related gene EWSR1 in amyotrophic lateral sclerosis.

Human molecular genetics - 1 Jul 2012

Couthouis Julien, Hart Michael P, Erion Renske, King Oliver D, Diaz Zamia, Nakaya Tadashi, Ibrahim Fadia, Kim Hyung-Jun, Mojsilovic-Petrovic Jelena, Panossian Saarene, Kim Cecilia E, Frackelton Edward C, Solski Jennifer A, Williams Kelly L, Clay-Falcone Dana, Elman Lauren, McCluskey Leo, Greene Robert, Hakonarson Hakon, Kalb Robert G, Lee Virginia M Y, Trojanowski John Q, Nicholson Garth A, Blair Ian P, Bonini Nancy M, Van Deerlin Vivianna M, Mourelatos Zissimos, Shorter James, Gitler Aaron D

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease affecting motor neurons. Mutations in related RNA-binding proteins TDP-43, FUS/TLS and TAF15 have been connected to ALS. These three proteins share several features, including the presence of a bioinformatics-predicted prion domain, aggregation-prone nature in vitro and in vivo and toxic effects when expressed in multiple model systems....

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Identifiers

PMID: 22454397
DOI: 10.1093/hmg/dds116
PMCID: PMC3373238

Genes

EWSR1
FUS
TAF15

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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