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Article

Loss of Nuclear TDP-43 Is Associated with Decondensation of LINE Retrotransposons

1 Apr 2019

Abstract excerpt

Loss of the nuclear RNA binding protein TAR DNA binding protein-43 (TDP-43) into cytoplasmic aggregates is the strongest correlate to neurodegeneration in amyotrophic lateral sclerosis and frontotemporal degeneration. The molecular changes associated with the loss of nuclear TDP-43 in human tissues are not entirely known. Using subcellular fractionation and fluorescent-activated cell sorting to enrich for...

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PMID: 31042469
DOI: 10.1016/j.celrep.2019.04.003

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