Article
Induced in vivo knockdown of the Brca1 gene in skeletal muscle results in skeletal muscle weakness.
The Journal of physiology - 1 Feb 2019
Tarpey Michael D, Valencia Ana P, Jackson Kathryn C, Amorese Adam J, Balestrieri Nicholas P, Renegar Randall H, Pratt Stephen J P, Ryan Terence E, McClung Joseph M, Lovering Richard M, Spangenburg Espen E
Abstract excerpt
KEY POINTS: Breast cancer 1 early onset gene codes for the DNA repair enzyme, breast cancer type 1 susceptibility protein (BRCA1). The gene is prone to mutations that cause a loss of protein function. BRCA1/Brca1 has recently been found to regulate several cellular pathways beyond DNA repair and is expressed in skeletal muscle. Skeletal muscle specific knockout of Brca1 in mice caused a loss of muscle quality,...
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