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Article

Expression quantitative trait loci and receptor pharmacology implicate Arg1 and the GABA-A receptor as therapeutic targets in neuroblastoma.

Cell reports - 6 Nov 2014

Hackett Christopher S, Quigley David A, Wong Robyn A, Chen Justin, Cheng Christine, Song Young K, Wei Jun S, Pawlikowska Ludmila, Bao Yun, Goldenberg David D, Nguyen Kim, Gustafson W Clay, Rallapalli Sundari K, Cho Yoon-Jae, Cook James M, Kozlov Serguei, Mao Jian-Hua, Van Dyke Terry, Kwok Pui-Yan, Khan Javed, Balmain Allan, Fan QiWen, Weiss William A

Abstract excerpt

The development of targeted therapeutics for neuroblastoma, the third most common tumor in children, has been limited by a poor understanding of growth signaling mechanisms unique to the peripheral nerve precursors from which tumors arise. In this study, we combined genetics with gene-expression...

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Source

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Identifiers

PMID: 25437558
DOI: 10.1016/j.celrep.2014.09.046
PMCID: PMC4251494

Genes

ARG1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25437558-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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