Proteomic profile of cystic fibrosis sputum cells in adults chronically infected withPseudomonas aeruginosa

Abstract excerpt

Lung disease is the main cause of morbidity and mortality in cystic fibrosis (CF), and involves chronic infection and perturbed immune responses. Tissue damage is mediated mostly by extracellular proteases, but other cellular proteins may also contribute to damage through their effect on cell activities and/or release into sputum fluid by means of active secretion or cell death. We employed MudPIT...

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