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Article

Integrated molecular pathway analysis informs a synergistic combination therapy targeting PTEN/PI3K and EGFR pathways for basal-like breast cancer.

BMC cancer - 2 Aug 2016

She Qing-Bai, Gruvberger-Saal Sofia K, Maurer Matthew, Chen Yilun, Jumppanen Mervi, Su Tao, Dendy Meaghan, Lau Ying-Ka Ingar, Memeo Lorenzo, Horlings Hugo M, van de Vijver Marc J, Isola Jorma, Hibshoosh Hanina, Rosen Neal, Parsons Ramon, Saal Lao H

Abstract excerpt

BACKGROUND: The basal-like breast cancer (BLBC) subtype is characterized by positive staining for basal mammary epithelial cytokeratin markers, lack of hormone receptor and HER2 expression, and poor prognosis with currently no approved molecularly-targeted therapies. The oncogenic signaling pathways driving basal-like tumorigenesis are not fully elucidated. METHODS: One hundred sixteen unselected breast tumors...

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Identifiers

PMID: 27484095
DOI: 10.1186/s12885-016-2609-2
PMCID: PMC4971667

Genes

EGFR
PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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