Article
Genetic data and cognitively defined late-onset Alzheimer's disease subgroups.
Molecular psychiatry - 1 Nov 2020
Mukherjee Shubhabrata, Mez Jesse, Trittschuh Emily H, Saykin Andrew J, Gibbons Laura E, Fardo David W, Wessels Madeline, Bauman Julianna, Moore Mackenzie, Choi Seo-Eun, Gross Alden L, Rich Joanne, Louden Diana K N, Sanders R Elizabeth, Grabowski Thomas J, Bird Thomas D, McCurry Susan M, Snitz Beth E, Kamboh M Ilyas, Lopez Oscar L, De Jager Philip L, Bennett David A, Keene C Dirk, Larson Eric B, Crane Paul K
Abstract excerpt
Categorizing people with late-onset Alzheimer's disease into biologically coherent subgroups is important for personalized medicine. We evaluated data from five studies (total n = 4050, of whom 2431 had genome-wide single-nucleotide polymorphism (SNP) data). We assigned people to cognitively defined subgroups on the basis of relative performance in memory, executive functioning, visuospatial functioning, and...
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