Article
Overexpression of caveolin-1 in a human melanoma cell line results in dispersion of ganglioside GD3 from lipid rafts and alteration of leading edges, leading to attenuation of malignant properties.
Cancer science - 1 Apr 2007
Nakashima Hideyuki, Hamamura Kazunori, Houjou Toshiaki, Taguchi Ryo, Yamamoto Noriyuki, Mitsudo Kenji, Tohnai Iwai, Ueda Minoru, Urano Takeshi, Furukawa Keiko, Furukawa Koichi
Abstract excerpt
Caveolin-1 is a component of lipid rafts, and is considered to be a tumor suppressor molecule. However, the mechanisms by which caveolin-1 functions in cancer cells are not well understood. We generated caveolin-1 transfectant cells (Cav-1(+) cells) using a human melanoma cell line (SK-MEL-28) and investigated the effects of caveolin-1 overexpression on the GD3-mediated malignant properties of melanomas. Cav-1(+)...
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