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Article

Promoter DNA methylation contributes to human β-defensin-1 deficiency in atopic dermatitis

4 May 2018

Abstract excerpt

Atopic dermatitis (AD) is a chronic inflammatory skin disease caused by epidermal barrier dysfunction and dysregulation of innate and adaptive immunity. Epigenetic regulation of human β-defensin-1 (HBD-1) might be associated with a variety of defects in the innate immune system during AD pathogenesis. We investigated the possible mechanism of decreased HBD-1 gene expression in AD and demonstrated the restoration...

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PMID: 30460095
DOI: 10.1080/19768354.2018.1458652

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