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Epigenetic alterations in skin homing CD4+CLA+ T cells of atopic dermatitis patients

22 Oct 2020

Abstract excerpt

Abstract T cells expressing the cutaneous lymphocyte antigen (CLA) mediate pathogenic inflammation in atopic dermatitis (AD). The molecular alterations contributing to their dysregulation remain unclear. With the aim to elucidate putative altered pathways in AD we profiled DNA methylation levels and miRNA expression in sorted T cell populations (CD4+, CD4+CD45RA+naïve, CD4+CLA+, and CD8+) from adult AD patients...

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PMID: 33093567
DOI: 10.1038/s41598-020-74798-z

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