Article

Impact of dupilumab and upadacitinib treatment on epigenetic and transcriptomic alterations in skin-homing T cells of atopic dermatitis patients

2025-04-30

Abstract excerpt

<h4>Background</h4> Biologic therapies, such as the IL-4 receptor alpha blocker dupilumab, and Janus kinase (JAK) inhibitors like upadacitinib, have revolutionized the management of atopic dermatitis (AD). However, prolonged treatment is necessary to sustain disease remission. While both therapies are clinically effective, only dupilumab has demonstrated successful dose reduction, suggesting potential disease-mod...

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Literature Corpus work: 494aea2d-5a79-514b-bc86-6deefcaa8c6b
DOI: 10.1101/2025.04.28.650924

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