[Gene Mutation and Acute Leukemia Transformation of Severe Congenital Neutropenia- Review].

doi:10.7534/j.issn.1009-2137.2017.05.053

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Article

[Gene Mutation and Acute Leukemia Transformation of Severe Congenital Neutropenia- Review].

Zhongguo shi yan xue ye xue za zhi - 1 Oct 2017

Chi Zuo-Hua, Zhu Ping

Abstract excerpt

Severe congenital neutropenia (SCN) is a rare disease of bone marrow failure. Absolute value of peripheral blood neutrophil of SCN significantly reduced. SCN has a high risk of transformation to myelodysplastic syndromes (MDS) / acute myeloid leukemia (AML). At present, there are 14 abnormal genes related to SCN, ELANE is the most common pathogenic gene, the main therapy of SCN is the application of granulocyte...

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PMID: 29070147
DOI: 10.7534/j.issn.1009-2137.2017.05.053

Genes

ELANE

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