Inherited Predispositions to Myeloid Neoplasms: Pathogenesis and Clinical Implications

Abstract excerpt

Myeloid neoplasms with and without preexisting platelet disorders frequently develop in association with an underlying germline predisposition. Germline alterations affecting ANKRD26 , CEBPA , DDX41 , ETV6 , and RUNX1 are associated with nonsyndromic predisposition to the development of myeloid neoplasms including acute myeloid leukemia and myelodysplastic syndrome. However, germline predisposition to myeloid...