APOL1 risk allele RNA contributes to renal toxicity by activating protein kinase R

doi:10.1038/s42003-018-0188-2

Article

APOL1 risk allele RNA contributes to renal toxicity by activating protein kinase R

30 Oct 2018

Abstract excerpt

Abstract APOL1 risk alleles associate with chronic kidney disease in African Americans, but the mechanisms remain to be fully understood. We show that APOL1 risk alleles activate protein kinase R (PKR) in cultured cells and transgenic mice. This effect is preserved when a premature stop codon is introduced to APOL1 risk alleles, suggesting that APOL1 RNA but not protein is required for the effect. Podocyte...

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