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Article

Sensory involvement in the SOD1-G93A mouse model of amyotrophic lateral sclerosis.

Experimental & molecular medicine - 31 Mar 2009

Guo Yan Su, Wu Dong Xia, Wu Hong Ran, Wu Shu Yu, Yang Cheng, Li Bin, Bu Hui, Zhang Yue Sheng, Li Chun Yan

Abstract excerpt

A subset of patients of amyotrophic lateral sclerosis (ALS) present with mutation of Cu/Zn superoxide dismutase 1 (SOD1), and such mutants caused an ALS- like disorder when expressed in rodents. These findings implicated SOD1 in ALS pathogenesis and made the transgenic animals a widely used ALS model. However, previous studies of these animals have focused largely on motor neuron damage. We report herein that the...

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Source

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Identifiers

PMID: 19293633
DOI: 10.3858/emm.2009.41.3.017
PMCID: PMC2679239

Genes

SOD1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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