Article
Promoter methylation, mutation, and genomic deletion are involved in the decreased NDRG2 expression levels in several cancer cell lines.
Biochemical and biophysical research communications - 22 Jun 2007
Liu Na, Wang Lifeng, Liu Xinping, Yang Qi, Zhang Jing, Zhang Wei, Wu Yousheng, Shen Lan, Zhang Yingqi, Yang Angang, Han Hua, Zhang Jian, Yao Libo
Abstract excerpt
Human NDRG2 (N-Myc downstream regulated gene 2) was identified as a candidate tumor suppressor gene due to its low expression in human glioma and other cancer tissues. However, the mechanisms that lead to inactivation of the NDRG2 gene remain unknown. In the present study, semi-quantitative RT-PCR and Western blot analysis were used to confirm that NDRG2 mRNA and protein levels are decreased in several cancer...
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